The Protective Effects of Atorvastatin on the Brain Injury and Neuronal Damage caused by Ischemia-reperfusion in Rats
نویسنده
چکیده
BACKGROUND AND OBJECTIVE: Stroke is the third main cause of mortality and the most important origin of disability in the world. Atorvastatin has been shown to have strong anti-inflammatory and antioxidant effects on various pathological conditions. This study aimed to investigate the possible protective effects of atorvastatin on neuronal injury and damage in an experimental model of focal cerebral ischemia in rats. METHODS: This experimental study was conducted on 32 male Wistar rats, divided in four groups of eight: the control group, ischemia control group, and ischemia treated with atorvastatin (pre-treatment and post-treatment groups). Cerebral ischemia was determined as 90 minutes of middle cerebral artery occlusion, and 24 hours of reperfusion. Atorvastatin (40 mg/kg) was injected intraperitoneally one hour before ischemia induction, and immediately after the initiation of reperfusion. Moreover, evaluation of motor neuron disorders (NDS index), lesion volumes (TTC dyes) and damage recognition were performed 24 hours after the occlusion of the middle cerebral
منابع مشابه
Neuroprotective Effects of Exercise on Brain Edema and Neurological Movement Disorders Following the Cerebral Ischemia and Reperfusion in Rats
Introduction: Cerebral ischemia and reperfusion causes physiological and biochemical changes in the neuronal cells that will eventually lead to cell damage. Evidence indicates that exercise reduces the ischemia and reperfusion-induced brain damages in animal models of stroke. In the present study, the effect of exercise preconditioning on brain edema and neurological movement disorders followin...
متن کاملThe Role of Peroxisome Proliferator Activator Receptor Alpha in Cerebral Ischemia-Reperfusion Injury; a Review Study
Peroxisome proliferator-activated receptor alpha (PPAR-α), which belongs to the nuclear receptor family of ligand-activated transcription factors, was first described as gene regulators for metabolic pathways including lipid metabolism, insulin sensitivity, and glucose homeostasis. Were raised. This nuclear receptor is widely expressed in various tissues, providing a wide range of effects to st...
متن کاملThe role of L-arginine and aerobic exercise in experimental renal ischemia reperfusion injury in male and female rats
Introduction: Renal ischemia/reperfusion (I/R) injury due to reactive oxygen species (ROS) formation is the main cause of acute kidney damage. Nitric oxide (NO) biosynthesis and oxidative stress are closely related to the pathogenesis of renal I/R injury. This study was undertaken to determine the effects of L-arginine (L-arg) as NO donor and aerobic exercise (EX) and also the combination of L-...
متن کاملNeuroprotective effects of crocin on the histopathological alterations following brain ischemia-reperfusion injury in rat
Objective(s): Some histopathological alterations take place in the ischemic regions following brain ischemia. Recent studies have demonstrated some neuroprotective roles of crocin in different models of experimental cerebral ischemia. Here, we investigated the probable neuroprotective effects of crocin on the brain infarction and histopathological changes after transient model of focal cerebral...
متن کاملProtective Effects of Nucleobinding-2 After Cerebral Ischemia Via Modulating Bcl-2/Bax Ratio and Reducing Glial Fibrillary Acid Protein Expression
Introduction: Nucleobinding-2 (NUCB2) or nesfatin-1, a newly identified anorexigenic peptide, has antioxidant, anti-inflammatory, and anti-apoptotic properties. Brain ischemia-reperfusion induces irreversible damages, especially in the hippocampus area. However, the therapeutic effects of NUCB2 have not been well investigated in cerebral ischemia. This study was designed for the first time to i...
متن کامل